Cockos REAPER

REAPER is a complete digital audio production application for computers, offering a full multitrack audio and MIDI recording, editing, processing, mixing and mastering toolset. REAPER supports a vast range of hardware, digital formats and plugins, and can be comprehensively extended, scripted and modified.

Feature Highlights
Efficient, fast to load, and tightly coded. Can be installed and run from a portable or network drive.
Powerful audio and MIDI routing with multichannel support throughout.
64-bit internal audio processing. Import, record to, and render to many media formats, at almost any bit depth and sample rate.
Thorough MIDI hardware and software support.
Support for thousands of third-party plug-in effects and virtual instruments, including VST, VST3, AU, DX, and JS.
Hundreds of studio-quality effects for processing audio and MIDI, and built-in tools for creating new effects.
Automation, modulation, grouping, VCA, surround, macros, OSC, scripting, control surfaces, custom skins and layouts.